Pre-clinical and international trials confirm multi-targeted botanical formulation delivers 100 percent larval mortality and disrupts environmental tick life cycles without synthetic insecticides.
BENGALURU, INDIA — September 3, 2026 — Veterinary wellness pioneer Pet Natural Remedy has published comprehensive trial findings validating the clinical efficacy of its dual-action tick and flea management system, led by Nomoticks Xtra Anti-Tick and Flea Body Spray.
Ticks remain one of the most critical ectoparasitic threats in modern veterinary medicine, serving as primary biological vectors for severe canine haemoparasites including Babesia, Ehrlichia, Anaplasma, and Hepatozoon species. With traditional chemical parasiticides facing growing challenges related to chemical resistance, dermal sensitivity, and toxicity risks in young animals, the trial results highlight a verified plant-based alternative for comprehensive vector control.
The publication integrates rigorous in vitro laboratory evaluations, real-world field trials in India, and corroborating international clinical research published in the OnLine Journal of Biological Sciences.
Key Pre-Clinical and In Vitro Laboratory Findings
Laboratory testing of Nomoticks Xtra evaluated against common domestic tick vectors (Rhipicephalus sanguineus and Rhipicephalus microplus) demonstrated rapid insecticidal and acaricidal action:
- Adult Immersion Test (AIT): Delivered immediate immobilization upon contact, documented progressive mortality within 24 hours, and achieved 100 percent mortality within 48 hours post-treatment.
- Larval Immersion and Packet Tests (LIT/LPT): Recorded 100 percent larval mortality across both test methods, verifying complete lethality against intermediate life stages.
Multi-Targeted Mode of Action
Unlike single-molecule synthetic chemicals that can induce rapid parasite tolerance, Nomoticks Xtra leverages a synergistic complex of standardized phytoactives:
- Nimba (Azadirachta indica) Seed Oil: Disrupts acetylcholinesterase (AChE) and octopamine receptors in the parasite nervous system while causing mechanical degradation to the salivary gland and gut epithelium.
- Guggulu (Commiphora wightii) Bark Oil: Delivers targeted ovicidal and larvicidal activity, arresting embryonic development in eggs and intermediate nymph stages.
- Kattrna (Cymbopogon citratus) Leaf Oil: Dissolves protective exoskeleton waxes, accelerating desiccation while providing long-lasting natural repellent action against reinfestation.
In Vivo Field Efficacy and Off-Host Environmental Control
Because up to 80 percent of a tick population resides off the host in domestic environments (such as cracks, crevices, and pet bedding), effective control requires breaking the reproductive cycle both on and off the animal.
Field trials monitoring naturally infested companion animals and environmental resting areas revealed:
- On-Host Animal Clearance: Complete clearance of active tick infestations was achieved within 48 to 72 hours following treatment.
- Off-Host Ovicidal Action: Environmental application on infested bedding and animal quarters neutralized adult and larval populations within 24 hours while halting tick egg development and preventing subsequent hatching.
- Dual Protection Protocol: To prevent reinfestation, the protocol incorporates Nomoticks Home Spray and Nomoticks Xtra Body Spray to ensure 360-degree coverage across indoor living spaces and pet resting zones.
“Managing tick-borne diseases requires addressing the entire parasite lifecycle, from eggs hidden in flooring to adult ticks feeding on pets,” said Ayush Agarwal, Business Head at Pet Natural Remedy. “The trial data proves that scientifically standardized botanicals can achieve 100 percent tick elimination without subjecting puppies, or household environments to synthetic chemicals.”
Safety Profile for Multi-Pet Households
Nomoticks Xtra is formulated to be non-toxic,lick safe, steroid-free, and safe for dogs, cats, puppies,of all breeds. Manufactured in ISO 9001:2015 and GMP-certified facilities with official Ayush licensing, the spray delivers long-lasting protection while maintaining high safety standards for domestic application.
To review product specifications or place retail orders, visit PetNaturalRemedy.com
